Mother-to-child transmission of HBV: Review of current clinical management and prevention strategies

Mother-to-child transmission (MTCT) of HBV is responsible for approximately half of the HBV transmission routes and continues to be a challenging problem worldwide. Even after the development of effective vaccines and clear World Health Organization guidelines toward HBV several decades ago, 1-9% newborns of HBV-carrying mothers still acquire HBV in early life as a result of in utero infection. The prevention of MTCT is of high importance, because chronically infected individuals function as a reserve for sustained HBV transmission, and 25% of them can develop asymptomatic liver cirrhosis and hepatocellular carcinoma. In this article, we review the canonical and novel HBV infection routes/mechanisms, influencing factors, diagnostic criteria, and interruption strategies for HBV MTCT. The preventative strategy of HBV MTCT has evolved from routine postpartum HB immune globulin (HBIG) plus HB vaccine schedules to administration of HBIG or nucleoside analogs during pregnancy and minimizing the exposure of maternal body fluids to the newborn during delivery. © 2014 John Wiley & Sons, Ltd.

Ma L.1 , Alla N.R.2 , Li X.1 , Mynbaev O.A. 3, 5, 6 , Shi Z.1, 4
John Wiley and Sons Ltd
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  • 1 Department of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
  • 2 Department of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, United States
  • 3 Department of ObGyn and Reproductive Medicine, Moscow State University of Medicine and Dentistry, Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 4 Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA, United States
  • 5 The International Translational Medicine and Biomodeling Research Team, MIPT center for human physiology studies, The Department of Applied Mathematics, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russian Federation
  • 6 Laboratory of Pilot Projects, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation
Ключевые слова
hepatitis B antibody; hepatitis B vaccine; hepatitis B(e) antigen; nucleoside analog; amnion fluid; blood sampling; body fluid; breast feeding; childbirth; delivery; drug treatment failure; hepatitis B; Hepatitis B virus; human; immunoprophylaxis; intrauterine infection; maternal serum; newborn infection; passive immunization; puerperal infection; Review; umbilical cord blood; vertical transmission; virus transmission; adult; female; hepatitis B; Hepatitis B virus; male; mother; newborn; physiology; pregnancy; Pregnancy Complications, Infectious; prevention and control; transmission; vertical transmission; virology; Adult; Female; Hepatitis B; Hepatitis B virus; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Mothers; Pregnancy; Pregnancy Complications, Infectious
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