Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer

Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3′-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% - treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Copyright © Experimental Oncology, 2014.

Авторы
Kiselev V.I. 1 , Drukh V.M. 1 , Muyzhnek E.L.2 , Kuznetsov I.N.3 , Pchelintseva O.I. 1 , Paltsev M.A.4
Журнал
Издательство
Morion LLC
Номер выпуска
2
Язык
Английский
Страницы
90-93
Статус
Опубликовано
Том
36
Год
2014
Организации
  • 1 Peoples' Friendship University of Russia, Moscow 117198, Russian Federation
  • 2 ZAO MiraxBioPharma, Moscow 121248, Russian Federation
  • 3 Moscow State Medical Stomatological University (MGMSU), Moscow 127473, Russian Federation
  • 4 National Research Centre (NRC Kurchatov Institute), Moscow 123182, Russian Federation
Ключевые слова
3,3′-diindolylmethane; Anticancer activity; Bioavailability; LNCaP cell line; Preclinical studies; Xenograft model
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/5023/
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