The alpha-fetoprotein in prognosis of survival of and functional rehabilitation of patients with ischemic stroke

The study was carried out to determine the prognostic value of alpha-fetoprotein in development of lethal outcome and degree of functional rehabilitation of patients with ischemic stroke. The sampling included 216 patients in acute period of ischemic stroke. At the first day of development of disease they were measured the level of human alpha-fetoprotein. At the second day of disease patients were evaluated the degree of functional rehabilitation and the rate of lethal outcomes was calculated. Previously, the reference interval for alpha-fetoprotein was calculated according the guidelines of the International federation of clinical chemistry and national standard. The reference interval amounted to 0.59-3.78 mE/l. The study results demonstrated that low level of alpha-fetoprotein is related to higher risk of lethal outcome (SE=1.7, p=0.012). The increasing of level of alpha-fetoprotein over mentioned threshold value statistically significant increases probability of survival of patients. The further increasing more than 2.28 mE/l is related to subsequent good functional rehabilitation according the modifies Rankine scale (SE=1.4, p=0.001) and Barthel index (SE=I.49, p<0.001).

Авторы
Arkhipkin A.A.1 , Liang O.V. 1, 2 , Kochetov A.G. 1, 2
Издательство
Izdatel'stvo Meditsina
Номер выпуска
10
Язык
Русский
Страницы
12-15
Статус
Опубликовано
Год
2014
Организации
  • 1 Research Institute of Cerebral Vascular Pathology and Stroke, N.I. Pirogov Russian National Research Medical University Minzdrav of Russia, Moscow, 117997, Russian Federation
  • 2 Peoples' Friendship University of Russia, Moscow, 117198, Russian Federation
Ключевые слова
Alpha-fetoprotein; Functional rehabilitation; Ischemic stroke; Lethal outcome
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/4955/