Estradiol-17β receptors in cytosolic fraction of chondrosarcoma

Estradiol-17β receptors were detected in the cytosolic fraction of the majority of bone chondrosarcomas by protamine sulfate sedimentation of the hormone-receptor complex. The absolute number of receptors in tumors was higher in men than in women, but chondrosarcomas with estradiol-17β receptors more often occurred in women. The highest level of receptors was revealed in highly differentiated chondrosarcomas. No relationships between tumor location, size, type of the process, and the number of receptors was detected. We can state with assurance that the absence of estradiol-17β receptors in chondrosarcomas in women is a favorable prognostic sign with regard to metastases or local tumor relapses.