DNA methylation in the promoter regions of the laminin family genes in normal and breast carcinoma tissues

Extracellular glycoproteins of the laminin family are essential components of basement membranes involved in a number of biological processes, including tissue differentiation, wound healing, and tumorigenesis. We present the first comprehensive study of promoter methylation status of the genes encoding laminin chains in normal tissues (peripheral blood leucocytes, buccal epithelial cells, autopsy breast tissue samples) and in breast carcinoma samples. Based on the results of this study, we divide laminin genes into three categories. Genes, constitutively methylated in breast tissues include LAMA3A, LAMB2, LAMB3, and LAMC2. Genes prone to abnormal methylation in breast carcinoma include LAMA1, LAMA2, LAMA3B, LAMA4, LAMB1, and LAMC3. Genes that are rarely if ever methylated in breast carcinoma include LAMA5 and LAMC1. The constitutively methylated group includes all of the genes that encode subunits of laminin-5 (the historical name of laminin 332), the promoters of which were previously considered unmethylated in normal tissues and prone to abnormal methylation in breast cancer. © 2015, Pleiades Publishing, Inc.

Авторы
Simonova O.A.1 , Kuznetsova E.B.1, 2 , Poddubskaya E.V.3 , Kekeeva T.V.1 , Kerimov R.A.3 , Trotsenko I.D. 4 , Tanas A.S.1, 2, 5 , Rudenko V.V.1, 2 , Alekseeva E.A.1, 2 , Zaletayev D.V.1, 2, 5 , Strelnikov V.V.1, 2, 5
Редакторы
-
Журнал
Издательство
-
Номер выпуска
4
Язык
Английский
Страницы
598-607
Статус
Опубликовано
Подразделение
-
Номер
-
Том
49
Год
2015
Организации
  • 1 Research Centre for Medical Genetics, Moscow, 115478, Russian Federation
  • 2 Sechenov First Moscow State Medical University, Moscow, 199991, Russian Federation
  • 3 Blokhin Russian Research Center for Oncology, Moscow, 115478, Russian Federation
  • 4 Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 5 Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation
Ключевые слова
breast cancer; DNA methylation; laminin
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/4539/