Domino Staudinger/aza-Wittig/Mannich Reaction: An Approach to Diversity of Di- and Tetrahydropyrrole Scaffolds

A highly efficient and selective domino reaction producing valuable di- and tetrahydropyrrole-based skeletons from azidoethyl-substituted CH-acids and (thio)carbonyl compounds has been developed. By involving the additional functional groups in starting compounds into the domino reaction or postmodification of the primary reaction products, the simple construction of the pharmaceutically relevant three- and polycyclic azaheterocyclic scaffolds was demonstrated. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Авторы
Pavlova A.S.1 , Ivanova O.A. 1, 2 , Chagarovskiy A.O. 2, 3 , Stebunov N.S.1 , Orlov N.V.4 , Shumsky A.N.5 , Budynina E.M.1 , Rybakov V.B.1 , Trushkov I.V. 2, 3
Редакторы
-
Издательство
Wiley-VCH Verlag
Номер выпуска
50
Язык
Английский
Страницы
17967-17971
Статус
Опубликовано
Подразделение
-
Номер
-
Том
22
Год
2016
Организации
  • 1 Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russian Federation
  • 2 Laboratory of Chemical Synthesis, Federal Research Center of Pediatric Hematology, Oncology and Immunology n.a. Dmitriy Rogachev, Samory Mashela st., 1, Moscow, 117997, Russian Federation
  • 3 Faculty of Science, Russian University of People's Friendship, Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
  • 4 Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky pr. 47, Moscow, 119991, Russian Federation
  • 5 Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygina 4, Moscow, 119334, Russian Federation
Ключевые слова
azides; domino reactions; donor–acceptor cyclopropanes; nitrogen heterocycles; synthesis design
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/4445/