The research urgency is caused by necessity to find adequate solutions to the university students’ socio-cultural immune system formation to the challenges of modern anti-social and extremist behavior and activities norms. In this regard, priority attention in the article is devoted to establishing of the theoretical and methodological approaches to the development of mechanisms to manage social and cultural immunity of the students as a practical outcome of the educational process of the University. A leading research method is a method of pedagogical monitoring, which allowed in the course of continuous and ongoing monitoring of the process of students’ social and cultural immunity formation to justify the educational mechanisms of this process management. The article reveals the content of the concept “social and cultural immunity of University students”; based on the results of the study a complex of educational governance mechanisms of social and cultural immunity of the students has been revealed (basic knowledge and practical skills in educational activities; social and cultural ideals, as a condition of identification of the “I”; critical thinking); productivity of the identified complex has been proven using the motivational, cognitive, axiological and activities criteria of socio-cultural immunity development. Suggested in the article the results of the study may be useful for practical activities of teachers, educators and curators of universities. © 2016 Kosarenko et al.