Sensitivity of microbial associations of periodontal lesions to antibacterial agents

UNLABELLED: The aim of the study was the development of approaches to improve the effectiveness of antibiotic therapy in dental practice on the basis of determining the sensitivity of pathogenic microorganisms to antibiotics of different groups.MATERIAL AND METHODS: The study included determination of the sensitivity of the microbial complexes from wound exudate of periodontal pocket and apical abscess to macrolides, quinolones, penicillins, lincosamides and 5-nitroimidazole. A survey of dentists and dental clinics patients to identify the cause and frequency of use of antibiotics and to identify possible adverse reactions was also conducted.RESULTS: Dentists prefer macrolide antibiotics, protected penicillins, and fluoroquinolone combined with 5-nitroimidazole. All patients have taken antibiotics themselves at least once a year. Microbial complexes in patients with acute and exacerbated apical periodontitis in 79% of cases are susceptible to amoxicillin/clavulanic acid, to azithromycin - 52%, lincomycin - 36%, 5-nitroimidazole - 68%, ciprofloxacin - 73.7%. In patients with apical abscess high rates of resistance of microbial complexes to all types of antibiotics was revealed (33% for lincomycin 76,1% for ciprofloxacin, 28,6% for 5-nitroimidazole). Patients with moderate to severe periodontitis in 90.5% are sensitive to amoxicillin/clavulanic acid and azithromycin, in 62.4% to lincomycin. Sensitivity to ciprofloxacin was detected in 85.7% of patients, in 14.3% - moderate resistance.Abstract available from the publisher.

Авторы
Makeeva I.M.1 , Daurova F.Y. 2 , Byakova S.F.1 , Ippolitov E.V.3 , Gostev M.S.1 , Polikushina A.O.1 , Shubin E.V.1
Номер выпуска
3
Язык
Русский
Страницы
26-30
Статус
Опубликовано
Том
95
Год
2016
Организации
  • 1 First Moscow State Medical University, Moscow, Russia
  • 2 Russian Institute of People's Friendship, Moscow, Russia
  • 3 Moscow State Medical and Dental University, Moscow, Russia
Ключевые слова
antifungal agent; antiinfective agent; adult; antibiotic resistance; bacterium; drug effects; exudate; female; fungus; human; isolation and purification; male; microbiology; middle aged; Periapical Abscess; periodontal pocket; questionnaire; young adult; Adult; Anti-Bacterial Agents; Antifungal Agents; Bacteria; Drug Resistance, Microbial; Exudates and Transudates; Female; Fungi; Humans; Male; Middle Aged; Periapical Abscess; Periodontal Pocket; Surveys and Questionnaires; Young Adult
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/4303/
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