Pre-surgical and post-surgical alterations of arterial blood pressure circadian rhythm

BP was monitored before and after 10 surgical interventions of various complexity (2003-2010) in GSK (a patient of 76-84 years) suffering from hypertension disease since 1959. Treatment up to 09.2005 was performed traditionally (T, medications in mornings and evenings), later scheduled according to chronobiological principles, based on the 24- hour blood pressure (BP) profile. Changes in the parameters of the 24- and 12-hour components were analyzed during the 7 days preceding and the 7 days following each intervention. MESORs and acrophases did not change regularly after surgeries The magnitude (extent of predictable daily change determined from the composite model) did not change or even decreased on the days of operations but later began increasing (which could provoke sudden BP peaks), returning to initial values only within 6-7 days. In surgeries performed after T, inconsiderable increases in magnitude did not last more than 3 days or was absent altogether. As BP peaks may lead to many unfavorable effects, their reduction or disappearance after a chronobiologically scheduled treatment was implemented should be considered as a positive factor. Unfortunately, monitoring making this approach feasible is not realistic now, even in specialized surgical hospitals. © 2016 Nova Science Publishers, Inc.

Katinas G.S.1 , Astakhov Y.S.1 , Sedov S.M.1 , Yashin S.M.1 , Chibisov S.M. 1, 2 , Shastun S.A. 2 , Astakhov S.Y.1 , Boldyreva I.B.1 , Gromyko A.G.1 , Merkuryeva T.B.1 , Nefedova D.M.1 , Smirnov D.A.1 , Mitina E.V. 2
Сборник статей
Nova Science Publishers, Inc.
  • 1 I. P. Pavlov First State Medical University, St. Petersburg, Russian Federation
  • 2 People’s Friendship University of Russia, Moscow, Russian Federation
Ключевые слова
Blood pressures; Chronotherapy; Circadian function; Surgeries
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Другие записи

Ovsyannikov D.Y., Stepanova E.V., Belyashova M.A., Degtyareva E.A.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk. Том 71. 2016. С. 61-67