AIM: To define the role of endoscopic hemostasis in treatment of gastroduodenal ulcers complicated by bleeding.MATERIAL AND METHODS: The results of endoscopic hemostasis in 770 patients with peptic ulcers were analyzed.RESULTS: Injection hemostasis had the highest efficacy in case of recurrent bleeding. No other method showed significant advantage in its efficiency. The efficacy of injection method was 52%, argon-plasma coagulation - 83.3%, radiowave technique - 78%, combined endoscopic method - 96%. In case of recurrent bleeding endoscopic hemostasis is effective alternative to surgery especially in high-risk patients. Repeated endoscopic hemostasis significantly decreases mortality from 45% to 23% in case of recurrent bleeding.Abstract available from the publisher.