Rapid growth of the number of oncology diseases worldwide, including urothelial cancer (UC), dictates the need to develop new, innovative approaches to their treatment. The absence of clinical manifestations in the early stages of the disease does not allow the timely assignment of adequate therapy. On the other hand, traditional methods of treatment do not always have satisfactory efficacy, prevent recurrence, guaranty sufficient remission and lifetime of the patient. The treatment of invasive, metastatic cancer has significant difficulties. In this paper, we present an overview of modern traditional and innovative methods of UC treatment, including own developments, as well as an analysis of literature data on the use of specific immunotherapy methods in oncology.