Immunopathogenetic Comorbidity in Young Patients with Severe Plaque Psoriasis

Background Psoriasis is associated with multiple other comorbidities with a general inflammatory immune component, the most notable being cardiovascular (CVD) and metabolic disorders. But no study has been performed metabolic disorders in Russian population of Psoriasis (PsO) patients. Objectives To evaluate the prevalence of CV comorbidity, Obs, ThD and DM comorbidity in a hospital-based cohort of patients (pts) with severe PsO. Methods 330 patients (pts) (234 Male (M.)/96 Female (F.)), mean age 39.9 +/- 0.9/38.05 +/- 1.3 years accordingly, mean PASI 49.4 +/- 0.56, PsO duration 11.6 +/- 0.6 years were included. PsO pts with Endocrine, nutritional and metabolic diseases (E00-E90) (ENMD), including Obesity (Obs) and other hyperalimentation (E65-E68), diabetes mellitus (DM) (E10-E14) and PsO pts with cardiovascular disease (CVD), including coronary heart disease (CHID), arterial hypertension (AH), atherosclerosis and cerebrovascular accident (CVA) were identify in the hospital Database reporting and coding by International Statistical Classification of Disease and Related Health Problems (ICD-10) between 2010-2011 years. M +/- m, t-test, (%) were calculated. All p<0.05 were considered to indicate statistical significance. Results 130 out of 330 pts (39.4%) had CVD. CVD coding as I 00-I 99 were found significantly often in M. pts compare to F. pts - in 101 out of 234 pts (43.2%) and in 29 out of 96 pts (30.2%) accordingly (p<0.05). AH coding as I 10-I 15 were found in significantly more cases in M. pts compare to F. pts - in 90 out of 101 pts (90.1%) and in 24 out of 29 pts (82.7%) accordingly (p<0.05). 54 (34 M./20 - F.) out of 330 pts (16.4%) had ENMD. M. and F. pts were at the same age. Obs coding as E65-E68 were found in significantly more cases in F. pts compare to M. pts - in 13 out of 20 pts (65.0%) and in 19 out of 34 pts (55.9%) accordingly (p<0.05). DM coding as E10-E14 were found in significantly more cases in M. pts compare to F. pts - in 16 out of 34 pts (47%) and in 6 out of 20 pts (30%) accordingly (p<0.05). No significantly differences were found in the prevalence of CHD and Atherosclerosis coding as I 70 between M. and F. pts - in 7 out of 101 pts (6.9%) and in 1 out of 29 pts (4.1%) accordingly (p>0.05). Conclusions ENMD and CV comorbidities are common for hospital-treated cohort pts with severe plaque PsO. Young M. pts with severe plaque PsO significantly often suffer from DM compared to F. pts. Young F. pts with severe plaque PsO tend to suffer from obesity and other hyperalimentation compared to M. pts. Young M. pts with severe plaque PsO tend to suffer from CVD and AH compared to F. Pts. Immune-mediated inflammation is the central actor in atherogenesis beyond all risk factors.