Orderly muscle activity in elimination of erythrocytes microrheological abnormalities in rats with experimentally developed obesity
Background: Difficulties of the earliest stages' detection of erythrocytes' microrheological abnormalities' development at obesity are connected with falling out of clinicians' field of view of persons with first signs of this pathology. It dictates the necessity of experimental investigations' fulfillment on laboratory animals with just developed obesity in them. Earlier in this pathology, there was shown high efficiency of non-medication impacts in relation lowering of the value of body mass and weakening of thrombocyte and vascular dysfunctions. At the same time, there is still no clarity in the question about the impact of regular exercise on erythrocytes' microrheological features at the beginning of obesity development. Methods: 91 of health male-rats of Vistar line at the age of 2.5-3 months, into the investigation. 29 animals of them had experienced no impacts and composed the control group. 62 rats had obesity developed by prescribing them cardioangionefopathogenic semisynthetic diet. Then these rats were casually divided into experimental (32 rats) group and control group (30 rats). Rats from the experimental group during 60 subsequent days experienced daily exercise on a horizontal treadmill. There were used biochemical, hematological and statistical methods of investigation. Result: As the result of obesity development the rats turned out to have steady developing increase in systolic and diastolic pressure. At regular exercise, on the treadmill, the rats were noted to have a gradual At present fundamental medicine attentively examines early development stages of different pathology and mechanisms of its realization." taking into consideration their social aspects.' Traditionally in the focus of many researchers' attention, we can find functional and rheological features of basic regular blood elements and especially - their most numerous population - erythrocytes at rather widespread at present cardio-vascular and metabolic diseases. 6th Among them, one of the leading positions is occupied by developing under the impact of genetic predisposition and way of life obesity (OB) decrease of their values during 60 days of investigation to the level of the norm. During obesity development lipids' peroxidation activated in rats' erythrocytes because of activity weakening of their antioxidant protection. On the background of muscle activity in rats with obesity the content of lipids' peroxidation products in erythrocytes progressively decreased and by the 60th day of experiment reached the control level of healthy rats. At obesity development in rats, there was found a reliable decrease of erythrocytes-discocytes quantity in blood. It was accompanied by the increase of reversibly and irreversibly changed erythrocytes' quantity in examined animals' blood. Their values were returning to control the level of healthy rats during 60 days of regular muscle activity. At obesity development in rats, there was found the quick rise of erythrocytes' sum in aggregate and these aggregates' quantity at lowering of free erythrocytes' number. Their quantity returned to control values to the end of 60 days of exercise. During experimental obesity modeling, we noticed very early in rats' blood decrease of erythrocytes-discocytes' quantity, the level rise of their reversibly and irreversibly varieties with a strengthening of their aggregative ability. It takes place in the background of the weakening of erythrocytes' antioxidant protection and activation of lipids' peroxidation in them. Regular lasting muscle activity can eliminate existing erythrocytes' microrheological features' abnormalities in rats with recently developed obesity.