Assessing lithium nutritional status by analyzing its cumulative frequency distribution in the hair and whole blood

Objective: Lithium was recently proclaimed to be an essential trace element in human nutrition [1]. The aim of this study was to assess lithium nutritional status by analyzing lithium frequency distribution in the long-term biological indicator tissue of hair (H-Li) and in the short-term biological indicator tissue of whole blood (WB-Li). Materials and methods: Hair samples were analyzed in 1,073 apparently healthy adult Croats (339 males and 734 females) and the whole-blood lithium was analyzed in a random subsample of them (91 males and 143 females). Samples were analyzed using ICP-MS at the Center for Biotic Medicine, Moscow, Russia. Results: There were no gender-dependent differences in the lithium-adequate linear reference range for H-Li and WB-Li where lithium was (mu g x g(-1)) 0.014 - 0.100 and 3.40 - 5.65, respectively. Conclusion: Lithium concentrations below 0.014 mu g x g(-1) for H-Li and 3.40 mu g x g(-1) for WB-Li would indicate lithium deficiency. The estimated upper safety lithium limits for H-Li and WB-Li were set at 0.100 and 6.65 mu g x g(-1), respectively. These preliminary data are important for a long-term biomonitoring of low-level lithium supplementation.

Mimica N.1, 2 , Prejac J.3, 4 , Skalny A.A. 5, 6 , Grabeklis A.R. 7, 8, 9, 10 , Momcilovic B.11
Dustri-Verlag Dr. Karl Feistle
Номер выпуска
  • 1 Univ Psychiat Hosp Vrapce, Zagreb, Croatia
  • 2 Univ Zagreb, Sch Med, Zagreb, Croatia
  • 3 Univ Hosp Ctr Zagreb, Dept Oncol, Zagreb, Croatia
  • 4 Univ Zagreb, Sch Dent Med, Zagreb, Croatia
  • 5 Fed Med Biol Agcy, Fed State Sci Inst Inst Toxicol, St Petersburg, Russia
  • 6 ANO Ctr Biot Med, Russian Soc Trace Elements Med, Moscow, Russia
  • 7 Orenburg State Univ, Orenburg, Russia
  • 8 PG Demidov Yaroslavl State Univ, Yaroslavl, Russia
  • 9 RUDN Univ, Moscow, Russia
  • 10 All Russian Res Inst Med & Aromat Plants, Moscow, Russia
  • 11 Inst Res & Dev Sustainable Ecosyst IRES, Srebrnjak 59, Zagreb 10000, Croatia
Ключевые слова
lithium; nutritional status; hair; whole blood; safety limits
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