Association of the polymorphic variant g-105a of the seps1 gene and the polymorphic variant c3872t of the crp gene with preterm birth

Objective. To determine an association of the polymorphic variant G-105A of the SEPS1 gene and the polymorphic variant C3872T of the CRP gene with preterm birth in European women. Subjects and methods. Sixty-five women with preterm birth at 23.5 to 37 weeks’ gestation and 65 women with full-term pregnancy were genotyped. The polymorphic variant G-105A of the SEPS1 gene was determined by the polymerase chain reaction (PCR), followed by restriction analysis, the polymorphic variant C3872T of the CRP gene was done by the allele-specific PCR followed by electrophoretic detection. Results. There was an association of the polymorphic variant G-105A of the SEPS1 gene with the risk of preterm birth in Caucasian women. The frequency of the A allele of the SEPS1 gene was 20%, which was significantly higher than that in the control group (8%) (x2 = 5.025, p = 0.025). The incidence of heterozygotes was also considerably higher in the preterm birth group (x2 = 6.002; p = 0.014).There was no association of the T allele in the polymorphic variant C3872T of the CRP gene with preterm birth. Conclusion. The A allele in the polymorphic variant G-105A of the gene SEPS1 can act as one of the predictors of preterm birth. © 2019, Bionika Media Ltd. All Rights Reserved.

Авторы
Musalaeva I.O. 1 , Tarasenko E.V. 1 , Galina T.V. 1 , Zheludova E.M. 1 , Azova M.M. 1 , Kirbasova N.P.2 , Olenev A.S.3
Редакторы
-
Издательство
-
Номер выпуска
4
Язык
Русский
Страницы
34-38
Статус
Опубликовано
Подразделение
-
Номер
-
Том
2019
Год
2019
Организации
  • 1 Department of Obstetrics and Gynecology, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklaya str. 6, Moscow, 117198, Russian Federation
  • 2 I.M. Sechenov First Moscow State Medical University, Trubetskaya str. 8, p. 2, Moscow, 119991, Russian Federation
  • 3 City Clinical Hospital No. 24 DZM, Perinatal Center, 4th Vyatsky pereulok, 39, Moscow, 127287, Russian Federation
Ключевые слова
Genetic markers; Inflammation; Preterm birth; Spontaneous preterm birth
Дата создания
19.07.2019
Дата изменения
19.07.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/38900/