Objective. To determine an association of the polymorphic variant G-105A of the SEPS1 gene and the polymorphic variant C3872T of the CRP gene with preterm birth in European women. Subjects and methods. Sixty-five women with preterm birth at 23.5 to 37 weeks’ gestation and 65 women with full-term pregnancy were genotyped. The polymorphic variant G-105A of the SEPS1 gene was determined by the polymerase chain reaction (PCR), followed by restriction analysis, the polymorphic variant C3872T of the CRP gene was done by the allele-specific PCR followed by electrophoretic detection. Results. There was an association of the polymorphic variant G-105A of the SEPS1 gene with the risk of preterm birth in Caucasian women. The frequency of the A allele of the SEPS1 gene was 20%, which was significantly higher than that in the control group (8%) (x2 = 5.025, p = 0.025). The incidence of heterozygotes was also considerably higher in the preterm birth group (x2 = 6.002; p = 0.014).There was no association of the T allele in the polymorphic variant C3872T of the CRP gene with preterm birth. Conclusion. The A allele in the polymorphic variant G-105A of the gene SEPS1 can act as one of the predictors of preterm birth. © 2019, Bionika Media Ltd. All Rights Reserved.