The authors introduce and discuss a theory that looks at a contemporary Russian society as a community rapidly losing skills necessary for successful cross-cultural communication which entails not only the ability to communicate in the international space, but also knowledge related to cultural characteristics, national traditions, customs and history of different nations that is essential in building a cognitive basis for developing respectful relations to other national cultures and their representatives. It is the knowledge and understanding of other nation’s features and culture that forms the basis for developing the culture of interethnic dialogue. The purpose of the paper is to distinguish the factors that contributed to the destruction of the interethnic communication culture and tolerance crisis in the modern multiethnic space society. It is closely connected with a task of determining the conditions that could bring to the regeneration of interethnic communication as it is now considered the most important strategy for ensuring civilizational security. The polyphonic approach to study interethnic communication problems has been used as in a study to provide insights for the variable and subjective understanding of this phenomenon from the point of view of its integrity, versatility, variability, consistency, equivalence and equality of all the components of this phenomenon items. The authors have identified a number of factors that influence intensively the degradation process in interethnic communication. These factors include the destruction of a single international ideology, growth of national extremism, lack of effective national policy of the Russian state and the monoethnization in the national republics of Russia. The authors introduce their view on the principles of regeneration of the interethnic dialogue culture which imply the need for knowledge and understanding of traditions related to interethnic communication participants, understanding and improving relationships between ethnic groups, equality of the parties of communication, recognition of equal rights and obligations within the borders of the common civilization, a system of institutions involved in the reproduction process and ensuring its effectiveness. © 2019, Slovenska Vzdelavacia Obstaravacia. All rights reserved.