Three-component reaction of 3-arylidene-3H-indolium salts, isocyanides, and alcohols

A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesis of the above mentioned imidates from N-alkylindoles, aromatic aldehydes, aromatic isocyanides and alcohols was also proposed. In addition, it was shown that in the presence of water, aryl(indol-3-yl)methylium tetrafluoroborates reacted with isocyanides to furnish aryl(indol-3-yl)acetamides. © 2019 Golantsov, Nguyen, Golubenkova, Varlamov, Van der Eycken and Voskressensky.

Авторы
Журнал
Издательство
Frontiers Media S. A
Номер выпуска
MAY
Язык
Английский
Статус
Опубликовано
Номер
345
Том
7
Год
2019
Организации
  • 1 Department of Organic Chemistry, Faculty of Science, Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 2 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Leuven, Belgium
Ключевые слова
Aryl(indol-3-yl)methylium ions; Imidates; Indoleninium ions; Isocyanides; Multicomponent reactions
Дата создания
19.07.2019
Дата изменения
19.07.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/38813/