Intramolecular cascade annulation triggered by rhodium(III)catalyzed sequential C(sp 2 )–H activation and C(sp 3 )–H amination

A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp 2 )–H activation and C(sp 3 )–H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold forms the core of many natural products with pharmacological relevance. © 2019 Song et al.