Distribution of Polymorphisms of the Renin—Angiotensin System Genes (ACE, AGT, and AGTR1), ITGB3, and FTO in Pregnant Patients with Hypertensive Disorders

The study included pregnant women aged 23-41 years with preeclampsia and gestation-associated arterial hypertension at weeks 27-40 and patients with essential arterial hypertension developing under conditions of the metabolic syndrome and without it. Frequency analysis of polymorphisms of the renin—angiotensin system genes (ACE, AGT, and AGTR1), ITGB3, FTO and their associations confirmed the syndrome nature of hypertensive disorders in pregnancy. The presence allele T of AGT gene and/or allele C of AGTR1 gene in the genotype of patients with preeclampsia was associated with higher BP and pressure load over 24 h. Allele D of ACE gene was also essential for BP parameters (pressure load) in patients with preeclampsia and gestation-associated arterial hypertension. Due to high genetic heterogeneity of the preeclampsia syndrome and genetic differences in the incidence of the studied gene polymorphisms in preeclampsia and gestation-associated arterial hypertension, no direct associations between these gestation disorders and polymorphic markers of the renin—angiotensin system genes can be established. However, polymorphisms of the renin—angiotensin system genes are essential for the 24-h dynamics of BP and pressure load under conditions of hypertensive disorders in pregnancy. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Авторы
Zotova T.Y.1 , Lapaev N.N. 1 , Azova M.M. 2 , Blagonravov M.L. 1 , Gigani O.O. 2 , Ait Aissa A. , Denisova A.P. 1
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
1
Язык
Английский
Страницы
74-78
Статус
Опубликовано
Подразделение
-
Номер
-
Том
167
Год
2019
Организации
  • 1 V. A. Frolov Department of General Pathology and Pathophysiology, Moscow, Russian Federation
  • 2 Department of Biology and General Genetics, Medical Institute, Peoples’ Friendship University of Russia, Moscow, Russian Federation
Ключевые слова
arterial hypertension; gene polymorphism; pregnancy; renin—angiotensin system
Дата создания
19.07.2019
Дата изменения
19.07.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/38625/