Abstract: The application of geoinformatics and systems analysis methods for processing and interpreting geospatial data in geophysics and geodynamics is considered. The modern capabilities of observations with Global Navigational Satellite Systems as the main source of geospatial data are described. Achievements in the interpretation of geomagnetic data are presented and, in connection with this, some basic points of systems analysis are presented. The application of systems analysis in geophysics and geodynamics is illustrated by the approaches to estimating and forecasting the stability of the structural-tectonic blocks of the Earth’s crust for the geoecologically safe burial of high-level radioactive waste in the rocks of the Nizhne–Kanskii massif, Krasnoyarsk krai. © 2019, Pleiades Publishing, Ltd.