Initial mechanisms of the development of hypertonic heart

In rabbits, arterial hypertension was simulated according to Goldblatt. One, 2, 4, and 6 weeks after surgery, the hearts of control and experimental animals were extirpated for morphological examination. In semithin sections of the left and right ventricles, morphometry was performed using an Avtandilov grid. Ultrathin sections of these organs were examined under an electron microscope. It was found that the initial signs of myocardial hypertrophy appeared soon after hypertension modeling, and more early in the right ventricle. Activation of apoptosis was noted in cardiomyocytes of both ventricles, and its intensity correlated with the degree of myocardial hypertrophy. It is hypothesized that apoptosis limits the development of hypertrophy in the myocardium. © 2004 Plenum Publishing Corporation.

Авторы
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
3
Язык
Английский
Страницы
220-223
Статус
Опубликовано
Подразделение
-
Номер
-
Том
137
Год
2004
Организации
  • 1 Department of Pathological Physiol., Russian Univ. of People Friendship, Moscow, Russian Federation
  • 2 Institute of Pathology, Heidelberg University, Heidelberg, Germany
Ключевые слова
Apoptosis; Arterial hypertension; Hypertrophy; Myocardium
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/3664/