Mechanical Transformation of Compounds Leading to Physical, Chemical, and Biological Changes in Pharmaceutical Substances

This study demonstrates the link between the modification of the solid-phase pharmaceutical substances mechanical structure and their activity in waters with different molar ratio «deuterium-protium». Mechanochemical transformation of the powders of lactose monohydrate and sodium chloride as models of nutrients and components of dosage forms was investigated by the complex of physicochemical and biological methods. The solubility and kinetic activity of substances dispersed in various ways showed a positive correlation with the solvent isotope profile. Substances dissolved in heavy water were more active than solutes in natural water. Differential IR spectroscopy confirmed the modification of substituents in the sample of lactose monohydrate, demonstrating physicochemical changes during mechanical intervention. The biological activity of the compounds was determined by the method of Spirotox. The activation energy was determined by Arrhenius. Compared with the native compound, dispersed lactose monohydrate showed lower activation energy and, therefore, greater efficiency. In conclusion, proposed data confirm the statement that mechanical changes in compounds can lead to physicochemical changes that affect chemical and biological profiles. © 2018 A. V. Syroeshkin et al.

Редакторы
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Издательство
Hindawi Limited
Номер выпуска
-
Язык
Английский
Страницы
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Статус
Опубликовано
Подразделение
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Номер
8905471
Том
2018
Год
2018
Организации
  • 1 Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 2 Dumanskii Institute of Colloid and Water Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine
Ключевые слова
deuterium oxide; hydrogen; lactose; sodium chloride; analytic method; Article; biological activity; dispersity; dissolution; fluidization; Fourier transform infrared spectroscopy; grinding; histogram; kinetic isotope effect; kinetics; mechanics; particle size; pharmaceutics; physical chemistry; powder; spirotox
Дата создания
04.02.2019
Дата изменения
04.02.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/36531/