In actual conditions, the acute myocardium infarction is a main cause of population mortality factually in all countries. The purpose of study is to establish a prognostic significance of biochemical cardio-markers of blood and to develop prognostic models for acute myocardium infarction. The sampling included 157 patients with acute myocardium infarction and 138 healthy individuals. The cardio-markers in blood were analyzed using immune chromatographic and spectrometry techniques and also applying portable biochemical analyzer MultiCareJn (Italy). It is demonstrated that the highest prognostic value for development ofacute myocardium infarction is increasing of level of creatine kinase in blood more than 25 ME/I, troponin - more than 0.5 mkg'/, lactate dehydrogenase I - more than 200 ME/I and lactate dehydrogenase 2 - mpre than 180 ME/I. The developed regression model for prognosis of acute myocardium infarction according the indices mentioned above has a high sensitivity and specificity. Conclusion. The application ofprognostically significant cardio-markers of blood and developed regression model permits to forecast development of acute myocardium infarction and to implement prevention and treatment in earlier period. © 2018 Ruslania. All Rights Reserved.