Objective. To determine the rate of recurrent vaginal biocenotic disorders associated with bacterial vaginosis, their pattern, clinical features, and laboratory parameters in pregnant women with human papillomavirus (HPV) infection. Material and methods. A total of 682 pregnant women infected with HPV were examined. A PCR assay for HPV (Quantum-21), pH-metry, microscopy of vaginal smears, real-time PCR (Femoflor-16), and cervical cytological examination were used. Results. Among the 682 pregnant women infected with HPV, 38.7% had vaginal dysbiosis, of whom 48.1% had a recurrent course. The pattern of recurrent vaginal dysbiosis was marked by bacterial vaginosis (BV) in 34.7% of the patients; BV was concurrent with aerobic vaginitis and Candida vulvovaginitis in 44.1 and 18.1%, respectively; the concurrence of all the above infections was seen in 3.2%. The total rate of coinfections was 65.4%. Dysbiosis was clinically asymptomatic in 34.6% of the pregnant women. The mean pH values were 4.53±1.62 (95% CI, 4.04-5.02). In the presence of aerobic microorganisms, basal and parabasal cells were absent in the vaginal discharge at smear microscopy. Cervical intraepithelial changes occurred in every four patients; moreover, there were atypical squamous cells of undetermined significance (ASCUS) (12.6%), low-grade squamous intraepithelial lesions (LSIL) (11.8%), High-grade squamous intraepithelial lesions (HSIL) (0.8%). Conclusion. Pregnant women infected with HPV have a high incidence of vaginal dysbiosis of mixed etiology and its recurrences, as well as low-risk cervical intraepithelial lesions. © 2018, Bionika Media Ltd. All rights reserved.