Influence of Physical Activity on the Regulation of Iron Metabolism

Abstract: Intense physical activity has a significant effect on iron metabolism in the human organism. This paper is a review of world literature data focused on the mechanisms of iron metabolism regulation in the human organism, as well as the influence of intense exercise on these regulatory mechanisms. We have discussed the mechanisms of iron absorption and transport and the regulation of these processes under normal conditions. It has been found that intense exercise is accompanied by increased production of interleukin-6, a positive regulator of hepcidin production. Hepcidin, in turn, has an inhibitory effect on the expression of divalent metal transporter 1 and ferroportin, finally leading to both decreased iron absorption and iron sequestration in cells. All of the mentioned stages of iron deficiency development may be promising targets for correction of iron balance and working ability in patients exposed to intense physical activity. © 2018, Pleiades Publishing, Inc.

Авторы
Zaitseva I.P.1 , Tinkov A.A. 1, 2 , Skalny A.V. 1, 2, 3
Журнал
Номер выпуска
5
Язык
Английский
Страницы
592-599
Статус
Опубликовано
Том
44
Год
2018
Организации
  • 1 Demidov Yaroslavl State University, Yaroslavl, Russian Federation
  • 2 Russian University of Peoples’ Friendship, Moscow, Russian Federation
  • 3 All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russian Federation
Ключевые слова
hepcidin; inflammation; interleukin-6; iron deficiency; physical exercise; sports
Дата создания
04.02.2019
Дата изменения
04.02.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/36332/
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