Toxicological and nutritional status of trace elements in hair of women with in vitro fertilization (IVF) pregnancy and their 9-month-old children

The objective of the present study was to assess toxic and nutritional trace element and mineral status in hair of women with IVF pregnancy and their children. Inductively-coupled plasma mass-spectrometry was used to assess hair trace element levels of 50 women with IVF pregnancy and 158 controls with spontaneous pregnancy and their children. Women with IVF pregnancy were characterized by significantly elevated hair As, Hg, Li, K, Na, and reduced Fe, Si, and Zn contents. Children from IVF pregnancy had significantly lower values of hair Cr, Fe, Mg, Sr, and Al content when compared to the control values, whereas hair Hg and Mo levels were higher. Hair trace element levels were associated with pregnancy complications and infertility, but not newborn characteristics. The results suggest the need for preconceptional monitoring and correction of the levels of toxic and essential elements in women in order to improve the course pregnancy and child development. © 2018 Elsevier Inc.

Skalny A.V. 1, 2, 3 , Tinkov A.A. 1, 2 , Bohan T.G.4 , Shabalovskaya M.B.4 , Terekhina O.4 , Leshchinskaia S.B.4 , Agarkova L.A.5 , Notova S.V.6, 7 , Skalnaya M.G. 2 , Kovas Y.4, 8
Elsevier Inc.
  • 1 Yaroslavl State University, Yaroslavl, Russian Federation
  • 2 RUDN University, Moscow, Russian Federation
  • 3 All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russian Federation
  • 4 Laboratory for Cognitive Investigations and Behavioural Genetics, Tomsk State University, Tomsk, Russian Federation
  • 5 Research Institute of Obstetrics, Gynecology and Perinatology, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
  • 6 Orenburg State University, Orenburg, Russian Federation
  • 7 Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, Orenburg, Russian Federation
  • 8 Goldsmiths, University of London, London, United Kingdom
Ключевые слова
In vitro fertilization; Infertility; Pregnancy; Prenatal exposure
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