Continuous flow synthesis of amines from the cascade reactions of nitriles and carbonyl-containing compounds promoted by Pt-modified titania catalysts

The effective design of an active and stable catalytic system was performed by a simple modification of a commercial titania with a low platinum loading. The prepared material was fully characterized by XRD, XPS, N2 adsorption-desorption measurements, ICP-MS, TEM and SEM analyses. Such techniques corroborated the successful incorporation of Pt onto the titania surface, without affecting its original structure, morphology and chemical nature. The obtained TiO2-Pt catalyst was effectively applied in several continuous flow reactions between nitriles and carbonyl containing compounds for amine preparation. Remarkably, conversion of levulinic acid, a biomass derived molecule, was achieved with outstanding conversion (87%) and selectivity (80%) to 1-ethyl-5-methylpyrrolidin-2-one. The catalytic system demonstrated a high stability through 120 min of reaction. Moreover, the effect of the nitrile was investigated by performing the reaction with benzonitrile and ethylcyanoacetate. The TiO2-Pt catalyst was also tested in the conversion of benzaldehyde, displaying remarkable results. The influence of substitution in the aromatic ring was investigated using p-nitro-benzaldehyde and p-chloro-benzaldehyde. © 2019 The Royal Society of Chemistry.

Авторы
Altuǧ C.1, 2 , Muñoz-Batista M.J.2 , Rodríguez-Padrón D.2 , Balu A.M.2 , Romero A.A.2 , Luque R. 2, 3
Редакторы
-
Журнал
Издательство
Royal Society of Chemistry
Номер выпуска
2
Язык
Английский
Страницы
300-306
Статус
Опубликовано
Подразделение
-
Номер
-
Том
21
Год
2019
Организации
  • 1 Department of Chemistry, Bolu Abant Izzet Baysal University, Bolu, 14030, Turkey
  • 2 Departamento de Química Orgánica, Universidad de Córdoba, Campus de Rabanales Edificio Marie Curie (C-3), Ctra Nnal IV-A Km 396, Cordoba, E14014, Spain
  • 3 Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., Moscow, 117198, Russian Federation
Ключевые слова
-
Дата создания
04.02.2019
Дата изменения
04.02.2019
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/36148/