Chronobiology's progress. Part II, chronomics for an immediately applicable biomedicine

Chronomic cardiovascular surveillance serves to recognise and treat any risk elevation as well as overt disease, and to ascertain whether treatment is effective and, if so, for how long treatment effects lasts, be it for lowering an increased risk and/or in surveilling the success or failure of treatment. A treatment-associated increase in circadian amplitude of blood pressure (BP) may induce iatrogenic overswinging, also dubbed CHAT (circadian hyper-amplitude-tension), in some patients, thereby increasing cardiovascular disease risk unknowingly to care provider and receiver. © Halberg and J. Appl. Biomed.

Halberg F.1 , Cornélissen G.1 , Katinas G.1 , Tvildiani L.2 , Gigolashvili M.3 , Janashia K.4 , Toba T.1 , Revilla M.5 , Regal P.1 , Sothern R.B.1 , Wendt H.W.1 , Wang Z.6 , Zeman M.7 , Jozsa R.8 , Singh R.B.9 , Mitsutake G.10 , Chibisov S.M. 11 , Lee J.1 , Holley D.12 , Holte J.E.1 , Sonkowsky R.P.1 , Schwartzkopff O.1 , Delmore P.13 , Otsuka K.10 , Bakken E.E.14 , Czaplicki J.15
Номер выпуска
  • 1 Halberg Chronobiology Center, University of Minnesota, 420 Delaware St. S.E., Minneapolis, MN 55455, United States
  • 2 Department of Internal Medicine, Tbilisi State Medical University, Tbilisi, Georgia
  • 3 Georgian National Astrophysical Observatory, Tbilisi, Georgia
  • 4 Ministry of Labour, Health and Social Affairs of Georgia, Tbilisi, Georgia
  • 5 University of Valladolid, Valladolid, Spain
  • 6 Sichuan University, Chengdu, Sichuan, China
  • 7 Department of Animal Psysiology, Comenius University, Bratislava, Slovakia
  • 8 University Pecs, Pecs, Hungary
  • 9 Nutrition and Heart Centre, Halberg Hospital and Research Institute, Moradabad, India
  • 10 Tokyo Women's Medical University, Medical Center East, Tokyo, Japan
  • 11 People's Friendship University of Russia, Moscow, Russian Federation
  • 12 San Jose State University, San Jose, CA, United States
  • 13 Medtronic Inc., Fridley, MN, United States
  • 14 North Hawaii Community Hospital Inc., Kamuela, HI, United States
  • 15 Institute of Pharmacology and Structural Biology, CNRS, Paul Sabatier University, Toulouse, France
Ключевые слова
Blood pressure surveillance; CHAT; Chronobioethics; Food restriction; Health care
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