Pathophysiological aspects of functional modulation of human peripheral blood neutrophils with propranolol

We studied the effect of β-adrenoceptor antagonist propranolol on the regulation of spontaneous apoptosis in neutrophils, priming of lipopolysaccharide-treated neutrophils, and expression of neutrophil adhesion factors. The influence of propranolol on apoptosis, adhesion, and generation of oxygen radicals by neutrophils was shown to be an additional mechanism of the action of β-adrenoceptor antagonists. This pathophysiological mechanism probably mediates the effect of neuroendocrine transmitters and explains the role of adrenergic antagonists in the pathogenesis and therapy of inflammation, cardiovascular diseases, and bronchial asthma. © Springer Science+Business Media, Inc. 2006.

Авторы
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
6
Язык
Английский
Страницы
675-677
Статус
Опубликовано
Том
141
Год
2006
Организации
  • 1 Russian People's Friendship University, Russian Federation
Ключевые слова
Adhesion; Apoptosis; Neutrophils; Propranolol; Reactive oxygen species
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/3362/