Comparative analysis of dipsogenic effects of systemic and intracerebral injection of angiotensin II to rats after carotid glomectomy

Systemic administration of angiotensin II after carotid glomectomy produced a less pronounced dipsogenic effects (consumption of water and NaCl solution) compared to sham-operated control animals. Injection of angiotensin II into the lateral cerebral ventricles of the same glomectomized rats increased water and NaCl consumption to a level surpassing that of sham-operated animals. The number of drinking acts and comfortable grooming acts decreased in glomectomized animals after systemic administration of angiotensin II, but increased after its intracerebral injection compared to the control. The results confirm the hypothesis that carotid chemoreceptors, as the peripheral component of the renin-angiotensin system, participate in the mechanisms of angiotensin-induced thirst, "salt appetite", and associated behavioral forms (comfortable grooming) synergically with the central cerebral receptors. © Springer Science+Business Media, Inc. 2006.

Авторы
Serova O.N.1 , Shevchenko L.V. 2 , Elfimov A.I. 2 , Lagutina L.V.1 , Kotov A.V. 1 , Torshin V.I. 2
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
1
Язык
Английский
Страницы
5-8
Статус
Опубликовано
Подразделение
-
Номер
-
Том
142
Год
2006
Организации
  • 1 Laboratory of Motivation Physiology, P. K. Anokhin Institute of Physiology, Russian Academy of Medical Sciences, Russian Federation
  • 2 Department of Normal Physiology, Medical Faculty, Russian University of Peoples' Friendship, Moscow, Russian Federation
Ключевые слова
Angiotensin II; Carotid body chemoreceptors; Carotid glomectomy; Renin-angiotensin system; Water-salt balance
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/3356/