Оценка эквивалентности антигипертензивных лекарственных средств по тесту «Растворение»

EQUIVALENCE ESTIMATES FOR ANTIHYPERTENSIVE DRUGS BY DISSOLUTION TES

The study was aimed to assess the equivalence of valsartan tablets of different manufacturers using in vitro dissolution study. Materials and methods: The dissolution was carried out using the apparatus II.Results: A similarity factor (f2) was employed. Samples with pH 1.2 and 4.5 showed the value more than 50%. Samples in pH 6.8 attained more than 85% dissolution within 15 minutes. Сonclusions: Studied tablets are equivalent to original drug.