Reduction of alcohol dependence in rats after carotid glomectomy

Carotid glomectomy significantly reduced the degree of alcohol addiction in rats, which was induced over 12 weeks. After glomectomy, the mean weekly volume of alcohol consumed by alcoholic animals over 4 weeks was lower compared to the preoperation level, while water consumption significantly increased by the 3rd and 4th weeks after surgery. Control sham operation had no effect on ethanol and water consumption in alcoholic rats. Possible involvement of the local renin-angiotensin system in chemoreceptor cells of the carotid body into systemic mechanisms of alcohol dependence is discussed. © Springer Science+Business Media, Inc. 2007.

Авторы
Serova O.N.1 , Shevchenko L.V. 2 , Elfimov A.I. 2 , Pevtsova E.I.1 , Torshin V.I. 2
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
5
Язык
Английский
Страницы
650-652
Статус
Опубликовано
Подразделение
-
Номер
-
Том
144
Год
2007
Организации
  • 1 Laboratory for Physiology of Motivations, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Russian Federation
  • 2 Department of Normal Physiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russian Federation
Ключевые слова
Alcohol dependence; Carotid body; Ethanol; Renin-angiotensin system
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/3187/