It was found that the performance assessment of quality of life in women have clearly defined monthly rhythm. The level of Vitality, Social Functioning values significantly higher in the follicular phase of the menstrual cycle and Physical Functioning, Role-Physical, General Health, Bodily Pain,, Role-Emotional, Mental Health luteal (p <0.05). It was found that the performance assessment of quality of life in women have a distinct seasonal rhythm. So, the maximum value of the PP were observed in winter, RoleEmotional, Bodily Pain and Vitality in the spring, Physical Functioning in the summer, and Role-Physical, General Health and Social Functioning autumn. Thus, the results of the evaluation of quality of life in healthy women of reproductive age are affected by how the monthly and seasonal biorhythms.