Induction of antimeningitis immunity by synthetic peptides. II. Immunoactive synthetic fragments of the OpaB protein from Neisseria meningitidis

Mice of various lines were immunized by 11 synthetic peptides that correspond to the sequences of fragments of the OpaB protein from the outer membrane of Neisseria meningitidis involving the known human T-helper epitopes and all the potential mouse T-helper epitopes calculated for the protein. The mice were immunized with the free peptides without their conjugation with a protein carrier. Most of the peptides were found to induce in mice the production of antipeptide antibodies. The mice protection against the experimental infection by a virulent strain of N. meningitidis of the B serotype was studied, and two peptides were shown to exert the most pronounced protective effect.

Авторы
Koroev D.O.1 , Volpina O.M.1 , Zhmak M.N.1 , Kupriyanova M.A.1 , Nesmeyanov V.A.1 , Alliluev A.P. 2 , Kotel'nikova O.V.1 , Ivanov V.T.1
Редакторы
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Издательство
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Номер выпуска
1
Язык
Русский
Страницы
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Статус
Опубликовано
Подразделение
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DOI
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Номер
-
Том
27
Год
2001
Организации
  • 1 Shemyakin - Ovchinnikov Inst. B., Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP-7 Moscow, 117871, Russian Federation
  • 2 Inst. of Gen. and Clinical Pathology, Peoples' Friendship Univ. of Russia, ul. Miklukho-Maklaya 6, Moscow, 117198, Russian Federation
Ключевые слова
Immunogenicity; Neisseria meningitidis; OpaB; Protective effect; Synthetic peptides
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/295/