Polymorphism of the catalase and glutathione peroxidase genes and macrovascular complications in non-insulin-dependent diabetic hypertensives

Allelic and genotypic distributions of the polymorphic markers Cl 167T and Prol97Leu of the genes of catalase (CAT) and glutathione peroxidase (GPX1), respectively, were studied in patients with non-insulin-dependent diabetes mellitus (NIDDM) and hypertension without complications (the control group, n = 52) and with complications: myocardial infarction (MI, n = 53) or stroke (n - 50). No significant differences were found between complicated and uncomplicated patients with respect to the allelic or phenotypic distribution. Thus, there were no association between these polymorphic regions and either MI or stroke in hypertensive NIDDM patients.

Авторы
Sergeeva T.V.1 , Chistyakov D.A. 2 , Kobalava Z.D. 1 , Moiseev V.S. 2
Редакторы
-
Журнал
Издательство
-
Номер выпуска
3
Язык
Английский
Страницы
418-421
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
37
Год
2001
Организации
  • 1 State Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow 113545, Russian Federation
  • 2 University of Peoples' Friendship, Moscow 117272, Russian Federation
Ключевые слова
catalase; glutathione transferase; article; cardiovascular disease; enzymology; genetic polymorphism; genetics; human; hypertension; non insulin dependent diabetes mellitus; phenotype; Cardiovascular Diseases; Catalase; Diabetes Mellitus, Type 2; Glutathione Transferase; Humans; Hypertension; Phenotype; Polymorphism, Genetic
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/288/