The role of adiponectin in development and progression of cardiovascular diseases

Arterial hypertension, insulin resistance, diabetes mellitus are associated with obesity. However exact mechanisms of this association have not been determined yet. Biologically active substances produced by adipose tissue participate in pathogenesis of cardiovascular diseases and complications. In this review we present data on the role of adiponectin - adipocytokine with unique antiatherogenic, antiinflammatory, and insulin sensitizing properties. Hypoadiponectinemia is considered to be potentially modifiable cardiovascular risk factor and novel therapeutic target. Therapy with PPAR gamma agonists, blockers of renin-angiotensin and sympathetic nervous systems is associated with elevation of concentration of adiponectin.

Журнал
Издательство
KlinMed Consulting
Номер выпуска
1
Язык
Русский
Страницы
51-58
Статус
Опубликовано
Том
49
Год
2009
Организации
  • 1 Russian University of Peoples Friendship, ul. Vavilova 61, 117292 Moscow, Russian Federation
Ключевые слова
Adipocytokines; Adiponectin; Arterial hypertension; Metabolic syndrome
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/2855/
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Другие записи

Sachivkina N.P., Kravtsov E.G., Vasilyeva E.A., Anokhina I.V., Dalin M.V.
Бюллетень экспериментальной биологии и медицины Клеточные технологии в биологии и медицине. New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук. Том 148. 2009. С. 214-216