Possible mechanism of regression of myocardial hypertrophy

Structure of the myocardium was studied in rabbits with renovascular hypertension during the development of myocardial hypertrophy and its regression under the effect of β-adrenoceptor antagonist lopressor. Myocardial hypertrophy was associated with ultrastructural changes in cardiomyocytes, while lopressor therapy led to their regression and normalization of cardiomyocyte ultrastructure. Regression of hypertrophic changes was accompanied by a marked increase in the number of extracellular nuclei, which indicated enhanced apoptosis of cardiomyocytes.

Авторы
Frolov V.A. 1 , Drozdova G.A.1 , Mustyatsa V.F.1 , Rieger P.2 , Antoni Z.2 , Kuzovkin A.E.1
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
1
Язык
Английский
Страницы
644-646
Статус
Опубликовано
Подразделение
-
Номер
-
Том
132
Год
2001
Организации
  • 1 Department of Pathological Physiology, Russian University of People Friendship, Moscow, Russian Federation
  • 2 Laboratory of Electronic Physiology, Institute of Pathology, Heidelberg University, Germany
Ключевые слова
β-adrenoceptor antagonist; Apoptosis; Myocardial hypertrophy; Regression
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/283/