Biorhythmologic aspects of seizure activity

Seasonal and circadian rhythms of neuronal and organism resistance to convulsive effect of strychnine and penicillin were studied in vivo on mice and rats and in vivo on cultured mouse cerebellar sections. Resistance was assessed by the latency of seizures in mice and neuronal response to convulsants in sections. In the night and morning time (0:00-9:00) seizure resistance in mice increased: it manifested in longer latency and lower mortality compared to those in the day and evening time (12:00-21:00). Seizure resistance was minimum in autumn and maximum in winter. Neurons in cerebellar section were most resistant to the convulsive effect of penicillin in autumn and winter and least resistant in spring and summer. Circadian rhythms of cerebellar neuron resistance to convulsants were opposite, which attests to reciprocal relations between epileptogenic and antiepileptic (cerebellar) cerebral structures.

Авторы
Torshin V.I.1 , Vlasova I.G.1
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
5
Язык
Английский
Страницы
1025-1028
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
132
Год
2001
Организации
  • 1 Department of Normal Physiology, Russian University of People Friendship, Moscow, Russian Federation
Ключевые слова
Cerebellar section; Circadian and seasonal rhythms; Convulsion resistance of neurons and animals; Epileptic seizure
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/277/