Characteristics of central pulse wave in young men with various phenotypes of arterial pressure

In this work we compared parameters of central arterial pressure (AP) on the basis of analysis of pulse wave in young men in dependence of AP phenotype determined by repetitive clinical measurements and 24 hour AP monitoring (24HAPM). Comparison of characteristics of central pulse wave was carried out in 12 men with normal AP, 36 men with arterial hypertension (AH) according to clinical measurements and 24HAPM, and 17 men with white coat hypertension (WCH). Mean age was 21.0±2.1 years. Differences in levels of pulse pressure (PP) between groups with AH were revealed only at the level of the aorta. Studied patients with normal AP and 24HAPM did not differ by such characteristics as index of increment and reflected wave appearance time. Studied patients with AH confirmed by 24HAPM were characterized by significantly greater augmentation of central PP (100.0±12.6% vs 96.6±11.8% in persons with normal AP and 95.6±15.0% with WCH, p<0.05), earlier appearance of reflected wave (149.2±18.9 ms vs 160.6±16.2 and 160.3±28.6 ms, respectively, p<0.05), high rate of pulse wave propagation (8.6±1.2 m/s vs 7.2±1,2 and 7.0±1.7 m/s). Amplification was similar in three groups. The data obtained has shown that in men aged 18-25 years presence of AH, confirmed by 24HAPM) is associated with elevation of central systolic AP and PP and higher values of markers of both rigidity of the aorta and remodeling of peripheral vascular bed.