Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation

We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells. © 2012 Springer Science+Business Media New York.

Авторы
Kalinina E.V. 1 , Berezov T.T. 1 , Shtil A.A.2 , Chernov N.N. 1 , Glazunova V.A.2 , Novichkova M.D. 1 , Nurmuradov N.K. 1
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
6
Язык
Английский
Страницы
879-882
Статус
Опубликовано
Подразделение
-
Номер
-
Том
153
Год
2012
Организации
  • 1 People's Friendship University of Russia, Moscow, Russian Federation
  • 2 N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation
Ключевые слова
Cisplatin; Drug resistance of tumor cells; Gene expression; Peroxiredoxin
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/2260/