Protective properties of recombinant IgA1 protease from meningococcus

The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form has shown that the active form of IgA1 protease exhibited species- and type-specificity for mouse and human immunoglobulins. A mutant form, lacking enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C; it protected mice from lethal infection by live virulent cultures of heterologous serogroups of meningococcus. The results obtained in this study suggest that IgA1 protease may be considered as a perspective preparation at the stages of development of a polyvalent vaccine for protection of human against meningococcal infections of various etiology. © 2013 Pleiades Publishing, Ltd.

Авторы
Kotel'nikova O.V. 1 , Alliluev A.P. 2 , Drozhzhina E.Yu.1 , Koroleva I.S. 3 , Sitnikova E.A.1 , Zinchenko A.A.1 , Gordeeva E.A.1 , Melikhova T.D.1 , Nokel E.A.1 , Zhigis L.S.1 , Zueva V.S.1 , Razgulyaeva O.A.1 , Serova O.V.1 , Yagudaeva E.Yu.1 , Rumsh L.D.1
Редакторы
-
Издательство
-
Номер выпуска
4
Язык
Английский
Страницы
305-310
Статус
Опубликовано
Подразделение
-
Номер
-
Том
7
Год
2013
Организации
  • 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation
  • 2 Medical Faculty, Russian University of Peoples' Friendship, Moscow, Russian Federation
  • 3 Municipal Infectious Diseases Hospital No. 2, Moscow, Russian Federation
Ключевые слова
enzymatic activity; IgA1 protease; immunogenicity; meningococcal vaccine; protective properties
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/2004/