Ki-67 and matrix metalloproteinase-9 expression in the follicular cyst, keratocystic odontogenic tumor, and ameloblastoma

An immunohistochemical study using antibodies against Ki-67 protein was conducted, which characterized the proliferative activity of cells and matrix metalloproteinase-9 (MMP-9) in follicular cyst, variants of keratocystic odontogenic tumor (with a preponderance of hyperkeratosis and parakeratosis), and ameloblastoma. The marked proliferative activity of a parabasal cell layer (28.0±8.4%) was found in the keratocystic odontogenic tumor with a preponderance of parakeratosis; the proliferative activity of the peripheral layer of ameloblastoma cells was equal to 7.0±5.6%. The maximal matrix metalloproteinase-9 expression in the keratocystic odontogenic tumor with a predominance of hyperkeratosis was 1.1 ±0.9 conventional units (CU) and that in the ameloblastoma was 1.9±1.3 CU versus 0.4±0.5 CU in the follicular cyst, keratocystic odontogenic tumor with a preponderance of hyperkeratosis. The values of Ki-67 and MMP-9 expression allow one to distinguish benign odontogenic cysts and tumors (follicular cyst and keratocystic odontogenic tumor with a predominance of hyperkeratosis) and odontogenic tumors characterized by an aggressive clinical course (keratocystic odontogenic tumor with a preponderance of parakeratosis and ameloblastoma).

Авторы
Babichenko I.I. 1 , Semkin V.A.2 , Usachev E.S.2 , Katushkina A.A. 1
Редакторы
-
Журнал
Издательство
-
Номер выпуска
1
Язык
Русский
Страницы
10-14
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
75
Год
2013
Организации
  • 1 Department of Pathological Anatomy, Medical Faculty, Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 2 Department of Surgical Dentistry, Central Research Institute of Dentistry and Maxillofacial Surgery, Ministry of Health of the Russian Federation, Moscow, Russian Federation
Ключевые слова
Ameloblastoma; Follicular cyst; Immunohistochemistry; Keratocystic odontogenic tumor
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/1935/