The effect produced by sodium salicylate, acetylsalicyclic, 2-3 dioxybenzoic and 2-3 diacetoxybenzoic acids on the blood clotting system and elimination of heparin (Russian)

Tests conducted on rabbits demonstrated that with a long term parenteral introduction (in amounts of 200 mg/kg, twice a day for 10 days) of 2-3 diacetoxybenzoic acid, sodium salicylate and acetylsalicylic acid, these compounds depress the coagulation potential of the blood, 2-3 diacetoxybenzoic acid also displaying a hypocoagulation action even with its single administration in a dose of 400 mg/kg. The mentioned substances raise the level of the endogenous blood heparin and reinforce the anticoagulative action of heparin; 2-3 dioxybenzoic acid lowers somewhat the concentration and the anticlotting effect of heparin.

Авторы
Редакторы
-
Издательство
-
Номер выпуска
4
Язык
Русский
Страницы
445-449
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
38
Год
1975
Организации
  • 1 Kaf. Farmakol., Med. Fak., Univ. Druzhby Narodov, Moscow
Ключевые слова
acetylsalicylic acid; dipyrocetyl; heparin; salicylate sodium; unclassified drug; acetylsalicylic acid; heparin; hydroxybenzoic acid derivative; salicylic acid derivative; blood clotting; oral drug administration; rabbit; theoretical study; animal; article; blood clotting; drug effect; metabolism; rabbit; Animal; Aspirin; Blood Coagulation; English Abstract; Heparin; Hydroxybenzoic Acids; Rabbits; Salicylates
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/1765/