The effect produced by sodium salicylate, acetylsalicyclic, 2-3 dioxybenzoic and 2-3 diacetoxybenzoic acids on the blood clotting system and elimination of heparin (Russian)

Tests conducted on rabbits demonstrated that with a long term parenteral introduction (in amounts of 200 mg/kg, twice a day for 10 days) of 2-3 diacetoxybenzoic acid, sodium salicylate and acetylsalicylic acid, these compounds depress the coagulation potential of the blood, 2-3 diacetoxybenzoic acid also displaying a hypocoagulation action even with its single administration in a dose of 400 mg/kg. The mentioned substances raise the level of the endogenous blood heparin and reinforce the anticoagulative action of heparin; 2-3 dioxybenzoic acid lowers somewhat the concentration and the anticlotting effect of heparin.