The first synthesis and X-ray crystal structure of tetrahydropyrrolo[2,3-d]azocines

Tetrahydropyrrolo[3,2-c]pyridines (THPP) upon the reaction with DMAD in acetonitrile or DMSO at rt underwent ring expansion, affording tetrahydropyrrolo[2,3-d]azocines; these latter compounds have not previously been reported in the literature. The crystal structure and conformation of these derivatives was established by X-ray crystallography. © 2002 Published by Elsevier Science Ltd.