Three-Component Synthesis of Tetrahydroisoquinolines via SNVin Reaction

The three-component reaction of carbocyclic enamino ketones, CH acids, and electrophiles has been studied. Previously unknown 5,6,7,8-tetrahydroisoquinoline derivatives have been synthesized via nucleophilic vinylic substitution (SNVin). The structures of some of the obtained compounds have been determined by X-ray analysis.

Авторы
Dyachenko I.V.1 , Dyachenko V.D.1 , Dorovatovskii P.V. 2 , Khrustalev V.N. 3, 4 , Nenajdenko V.G. 5
Журнал
Russian Journal of Organic Chemistry
Номер выпуска
9
Язык
Английский
Страницы
1619-1629
Статус
Опубликовано
Том
60
Год
2024
Организации
  • 1 Lugansk State Pedagogical University
  • 2 “Kurchatov Institute” National Research Center
  • 3 Peoplesʼ Friendship University of Russia
  • 4 Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
  • 5 Faculty of Chemistry, Moscow State University
Ключевые слова
three-component reactions; enamino ketones; CH Acids; Nucleophilic vinylic substitution; alkylation; 5,6,7,8-Tetrahydroisoquinolines
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