L-lysine α-oxidase: Physicochemical and biological properties

This review summarizes data on the properties of L-lysine α-oxidase, an enzyme that belongs to the group of oxidases of L-amino acids. This enzyme acts virtually only on L-lysine with a rather low Km yielding α-keto-ε-aminocaproic acid. The decrease in the level of the essential amino acid L-lysine and the formation of hydrogen peroxide during the reaction possibly provide the basis for the unique properties of L-lysine α-oxidase: cytotoxic, antitumor, antimetastatic, antiinvasive, antibacterial, and antiviral activities, as well as an immunomodulating effect. Native L-lysine α-oxidase and its immobilized forms are promising tools for determination of concentration of L-lysine in various biological materials.

Авторы
Редакторы
-
Журнал
Издательство
-
Номер выпуска
10
Язык
Английский
Страницы
1152-1158
Статус
Опубликовано
Подразделение
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Номер
-
Том
67
Год
2002
Организации
  • 1 Department of Biochemistry, Russian Peoples' Friendship Univ., ul. Miklukho-Maklaya 8, Moscow 117198, Russian Federation
Ключевые слова
Antibacterial enzyme; Antiinvasive effect; Antimetastatic effect; Antitumor enzyme; Antiviral enzyme; Enzymes in medicine; Immobilized enzymes; L-amino acid oxidase; L-lysine α-oxidase; L-lysine assay; Soluble enzyme conjugates
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/165/