Correlation of oral microbiota composition and sIgA in healthy individuals and patients with peri-implantitis; [Корреляция состава микробиоты полости рта и концентрации секреторного IgA в смешанной слюне у здоровых людей и пациентов с периимплантитом]

A study of oral microbiota through 16S rRNA metagenomic sequencing and secretory immunoglobulin A (sIgA) was conducted. The aim of the study was to evaluate the correlation between the results obtained by 16S rRNA sequencing method and the level of sIgA. Materials and methods. The study involved saliva from 18 patients with peri-implantitis aged between 18 and 80 years and 18 individuals with oral implants without pathological changes. Results. The level of secretory IgA in healthy individuals (1.1 g/L) and in patients with peri-implantitis (0.52 g/L) significantly differs. In peri-implantitis, the following types of bacteria predominate in the oral microbiome: Haemophilus parainfluenzae (9.3%), Fusobacterium nucleatum (4.8%), Porphyromonas gingivalis (3.3%), Veillonella dispar/parvula (9.4%), Haemophilus haemolyticus/influenzae (1.5%). Conclusion. A direct correlation has been identified between the level of sIgA in saliva and the diversity of microorganisms in the oral cavity of the subjects examined. © 2024 Clinical Dentistry LLC. All rights reserved.