The article describes a new method of laparoscopic treatment of perforated ulcers of the anterior wall and antrum of the stomach by forming a covered perforation with a duplication fold. The results of a comparative study of the effectiveness of a new method of laparoscopic treatment of covered perforation with a fold-duplication compared with the use of a two-row interrupted su-ture are presented. The technique of performing laparoscopic suturing of an ulcerative defect of the anterior wall of the stomach with the creation of a duplicate fold, the results of an experimental comparison of the state of the stomach wall in the operation area and a cytological analysis of changes in the gastric mucosa in the area of sutured perforation after both operations are de-scribed. The effectiveness and expediency of using the presented method for the treatment of a perforated ulcer of the anterior wall of the stomach with a duplication fold has been confirmed. Recommendations on the use of the main method in clinical practice have been written. © 2024, Media Sphera Publishing Group. All rights reserved.