The Study of Effectiveness of Combined Proton—Neutron Irradiation of Tumor Cells In Vitro

Combined proton—neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons. Treatment efficiency increased with increasing the contribution of the neutron component to the total dose from 30 to 40% and the delivery of the neutron dose as the first fraction in the two-fraction proton—neutron exposure. © Springer Science+Business Media, LLC, part of Springer Nature 2024.

Авторы
Koryakin S.N. , Troshina M.V. , Koryakina E.V. , Potetnya V.I. , Pichkunova A.A. , Saburov V.O. , Kazakov E.I. , Lychagin A.A. , Ivanov S.A. , Kaprin A.D. , Zverev V.I. , Presnyakov A.Y.
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Язык
Английский
Статус
Опубликовано
Год
2024
Организации
  • 1 A. Tsyb Medical Radiological Research Centre — Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russian Federation
  • 2 Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russian Federation
  • 3 National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russian Federation
  • 4 Dukhov Automatics Research Institute, Moscow, Russian Federation
Ключевые слова
cell survival; combined exposure; fast neutrons; protons; tumor cells
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